It's nearly certain that one day human beings (or our successors) shall somehow overcome natural death. It could be in twenty years or it could be in twenty thousand years, but that fact of the matter is that, unless all sapient life on Earth is eradicated, it's going to happen.
There are a variety of ways to which human beings could best mortality:
The enzyme
telomerase prevents bodily cells from dying and ultimately extends the life of the life-form. In 2008, a group of Spanish scientists managed to extend the lifespans of a population of genetically engineered mice. These mice, which produced tenfold the amount of telomerase that they would usually, lived about 50% longer each. Although high levels of the enzyme correlate with certain types of cancer, no negative effects were found in the mice. Dr. Maria Blasco, Spanish researcher who spearheaded the experiment, believed that existing cancer drugs could nullify this risk.
Now I usually don't like delving into transhumanism, but one of the main causes of that movement is the technological development of immortality. However, it's very likely that if or when immortality is achieved, it will be through the means of therapeutic cloning (replacement of dying bodily organs with healthy counterparts) or genetic engineering, such as the Spanish experiment mentioned above. Immortality by therapeutic cloning creates a conundrum much like the
Ship of Theseus. If a man has managed to live seven hundred years of youth by replacing all of his organs, perhaps even his brain, is he still the same man? These organs and appendages would be all grown from his DNA, but an arm cultured through this method would be much like the arm of a twin. In many ways, this seven-hundred man would be no more than a clone of the original person. Genetic engineering is much less morally muddled, but does carry a lot of baggage, due to its close relationship with eugenics. It's not hard to imagine another dictator emerging who attempts to create a "master race" of humans through DNA.
Certainly the slowest and most uncertain possible way to extend human life, some scientists think that immortality is the final destination in the evolution of any species.
Finally,
cryonics (not to be confused with the more definite science of cryogenics), or the process of freezing and thawing human beings like microwavable pizzas could probably lead to immortality. In normal cryonics, a person could live thousands of years or more in complete unconsciousness, as all brain activity has ceased. Although this
could allow a human being to live millions of years, they wouldn't have experienced life any more than a non-popsicle. If anything, this form of effective immortality is just a way to postpone death indefinitely.
No matter the method, the prospect of immortality carries several philosophical and spiritual problems with it.
One could argue that, after besting death, a human being would become disconnected from life. An immortal person could perhaps eventually harbor some kind of god delusion (c wut i did thar?), believing themself to have the characteristics of a deity. As the characteristics of a god have never been fully determined, or the existence of a god never proven, you can't empirically convince somebody that they
aren't a god. The disconnection from reality, mildly related to Aldo Leopold's Land Ethic, is a much more serious concern. Enough myths have told us that when humans grow proud and arrogant, it doesn't work well for them. On a realistic note, however, serious problems could arise if humans become immortal, particularly if only
some people are "above death".
Selective immortality, or a situation where only a select few of people have somehow beaten death, could be terrible. Very many, if not the majority, of terrible leaders throughout history ended their reign by dying naturally. Just last year, Kim Jong-Il died of natural causes and passed his power to his son. Some of the less rational Roman emperors and later imperial kings, such as Ivan the Terrible of Russia, only left the throne because of death. Imagine if a person with immense power but terrible intentions would be allowed to live forever. It's likely that unheard-of atrocities could occur, over unimaginable stretches of time.
Ignoring leaders, if immortals become a distinct class of people, huge issues could arise. This new bourgeoisie could easily rule over the rest cruelly, especially if they believe themselves to be superior over other humans. As immortality probably wouldn't come cheap, the first humans to evade death would probably be the most wealthy.
The death of death carries with it a slew of problems. Although the development of true immortality may be the single most significant event in human history, it isn't necessarily a good thing. What do you think of immortality? Given the opportunity, would you live forever?