Season one
Louie Anderson - As himself, hosting Family Feud in a J.D. fantasy
Jimmie Walker - As himself
Carrot Top - As Dr. Kelso after he removes his mask, in a J.D. fantasy
William Daniels - As a hospitalized "Dr. Douglas"
Stephen Furst - As a hospitalized "Dr. Franklyn"
Ed Begley, Jr. - As a hospitalized "Dr. Bailey"
Eric Laneuville - As a hospitalized "Dr. Lamar"
Season two
Colin Hay - As an unnamed troubadour
David Copperfield - As himself in a J.D. flashback
Jay Leno - As himself on the Tonight Show, in a J.D. fantasy
Fred "Rerun" Berry - As himself in a J.D. fantasy
Season three
Tara Reid - Danny, J.D.'s girlfriend
Maureen McCormick - As herself in a J.D. marriage fantasy
Erik Estrada - As himself in a J.D. flashback
The Polyphonic Spree - As themselves, performing when a member of their band is sick
Larry Thomas - As himself
George Takei - As a priest who bears a remarkable resemblance to Mr. Sulu