But, once again, what is the practical difference between a God who is totally uncaring about humanity and one who cares but must act as if he is an uncaring one due to his knowledge of the future?

Either way everything that happens is set in stone. For all intents and purposes they are identical.

As such, it would seem that Calvanism is right, we are all saved or damned before birth, may as well do as we please until we die.

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"Science is the poetry of reality" ~ Richard Dawkins