If we're talking about television in general, the saddest moment would have to go to the season finale of Grey's Anatomy... Yeah I watch the show, so what? Even men can watch medical dramas if they want to.

Ahem... (Spoilers for those who never saw it)

Imean, that was so unfair! Izzie should not have flatlined right after she had to go through Hell to get rid of those damned brain tumours. And then George, who got hit by the bus, and no one knew that it was him until it was too late. He died a hero, at least, but come on! That was out of nowhere!

So unfair...