All cells have a set division limit, no matter how large, and after a set limit, they simply use up resource but contribute nothing back.

Mass organ transplants would only be plausible for around 200 years or so. After that time, the skin cells would start dieing, and not replicating. Can you imaging dieing because the skin is falling off your body? I don't want to.

And for people saying a full body transplant is plausible, don't believe everything you see on Ghost in the Shell.

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Hazz=Spazz